Pistachios are one of the lowest calorie nuts, which means people can enjoy the health benefits of nuts while more easily staying within their daily calorie limits. Here are 9 evidence-based health benefits of pistachios. Loaded with nutrients. ... High in antioxidants. ... Low in calories yet high in protein. ... May aid weight loss. ... Promote healthy gut bacteria. ... May lower cholesterol and blood pressure. ... May promote blood vessel health. ... May help lower blood sugar.